The Signal Transduction & Therapeutics Program Area

JCCC MINI SYMPOSIUM:

High-throughput Screens in Signal Transduction and Translational Medicine

Monday, June 13th, 2011

ROUNDTABLE MEETINGS

CREB and Pancreatic Cancer
September 13,2010

Cancer Stem Cells
October 26, 2010

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PROGRESS REPORT SUBMITTED

The Progress Report for our program area was submitted on August. Scientific progress and achievements were outlined in areas including Signal transduction and tumor analysis and Clinical Translational Studies. The role of the Cancer Center and Future Plans were described. The Progress Report for our program area was submitted in August. Scientific progress and achievements were outlined in areas including Signal transduction and tumor analysis and Clinical Translational Studies. The role of the Cancer Center and Future Plans were described. Please see the highlights below and click here for the full report in pdf CCSG Progress Report 2010

Signaling Pathways: The mTOR signaling pathway the Pten/Akt Signaling CREB metformin GLP-1 metabolic changes in cancer cells small molecule inhibitors of pyruvate kinase M2

Global Analysis, Genomics,Proteomics: Large scale co-expression analysis of disease characterization, phosphoproteome analysis of aortic endothelial cells, salivary biomarkers, salivary miRNA for oral cancer detection

Inhibitors, Nanodelivery, therapy: small molecule inhibitor ABT-869, targeting liposomes, delivery of siRNA using mesoporous silica nanoparticles, significance of cancer stem cells for cancer therapy

Clinical Translational Studies

ErbB, PTEN/MTOR, IGF-1R, Hsp90

June 13th at 1:15 PM - location:BSRB 154
One day mini-symposium:
Title: "High-throughput Screens in Signal Transduction and Translational Medicine"
Sponsored by the Signal Transduction & Therapeutics Program, JCCC

Free Admission, Open to the Public, Refreshments Provided

Dec. 16, 2010 at 4pm -location:CHS 73-105
Guest Speaker Seminar:
Seminar Title: "MMSET, A Histone Methyl Transferase Alters Chromatin Structure And Gene Expression In Multiple Myeloma"
Jonathan Licht, Professor & Chief, Division of Hematology/Oncology
Associate Director, Clinical Sciences Research
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
*Co-sponsored with Heme malignancies

Nov. 23, 2010 at 12:00PM -location:CHS 73-105
Guest Speaker Seminar:
Seminar Title: "Small-molecule modulators of gene transcription: Rho signaling in prostate cancer and melanoma"
Professor Richard Neubig, Department of Pharmacology, University of Michigan

October 26, 2010 at 2:00PM - location CHS 73-105
Guest Speaker Seminar:
Seminar Title:"Hierarchical meso-domain organization of the plasma membrane for signal transduction: single-molecule tracking studies"
Professor Akihiro Kusumi, Professor, Institute for Integrated Cell-Material Sciences (iCeMS), Institute for Frontier Medical Sciences, Kyoto University.

October 13, 2010 at 12:00PM - location CHS 73-105
Guest Speaker Seminar:
Seminar Title: “Biology and Targeting of Leukemia Stem Cells”
Professor Ravi Bhatia, City of Hope Comprehensive Cancer Center (sponsored by Heme Malignancies and STT).

Course: Pathology M280 - Clinical Aspects and Molecular Biology of Bone Marrow Failure Syndromes - First Lecture Thursday, 1/6/2011

Featured article:
Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
Authors: Tara Lin, Qiuju Wang, Patrick Brown, Craig Peacock, Akil A. Merchant, Sarah Brennan, Evan Jones, Karen McGovern, D. Neil Watkins, Kathleen Sakamoto* and William Matsui* (*co-senior authors).
PLoS ONE, in press.

Major Component of Turmeric Enhances Chemotherapy Drug's Effect Against Head and Neck Cancer
Faculty: Eri Srivatsan, Ph.D., Marilene B. Wang, M.D.
Posted Date: 10/19/2010 10:15 AM

Chronic Stress Accelerates Cancer Progression in Mice
Faculty:Steve Cole, Ph.D., Patricia Ganz, M.D., Erica Sloan, Ph.D.
Posted Date:9/17/2010 9:30 AM

AUDIO: Dr. Anthony Heaney Discusses the Link Between Fructose and Pancreatic Cancer Growth
Listen to the audio.
(Note: The above file require an MP3 player such as RealPlayer ,QuickTime, or Windows Media Player.)
Posted Date: 8/4/2010 1:30 PM

Pancreatic Cancers Use Fructose, Common in a Western Diet, to Fuel Growth
Faculty:Anthony Heaney, M.D., Ph.D.
Posted Date: 8/3/2010 8:30 AM

Coming soon